Doctor › Prof. Mehtap ÇAKIR, MD
Home  ›  Doctors  ›  Prof. Mehtap ÇAKIR, MD
Prof. Mehtap ÇAKIR, MD

Specialty
Endocrinology and Metabolism Diseases

Academic Title
Professor Doctor

Education
Hacettepe University Faculty of Medicine (1987-1993)
Ankara University Faculty Of Medicine Dept. of Internal Medicine, 1994-1999 (Clinical Fellowship)

Publications
Laura C. Hernández-Ramírez, Plamena Gabrovska, Judit Dénes, Karen Stals, Giampaolo Trivellin, Daniel Tilley, Francesco Ferraù, Jane Evanson, Sian Ellard, Ashley B. Grossman, Federico Roncaroli, Mônica R. Gadelha, and Márta Korbonits, on behalf of The International FIPA Consortium: Amar Agha, MD; Scott A. Akker, MD; Elena D. Aflorei, MD; Sándor Alföldi, MD; Professor Wiebke Arlt, MD; Professor Brew Atkinson; Anna Aulinas-Masó, MD; Simon J. Aylwin, MD; Professor Philippe F. Backeljauw; Corin Badiu, MD; Stephanie Baldeweg, MD; Gul Bano, MD; Professor Ariel Barkan; Julian Barwell, MD; Carmen Bernal-González, MD; Professor G. Michael Besser; Professor John S. Bevan; Jo Blair, MD; Pierre Bouloux, MD; Lisa Bradley, MD; Michael Buchfelder, MD;Professor Mehtap Cakir; Natalie Canham, MD; Paul Carroll, MD; Harvinder S. Chahal, MD, PhD; Tim Cheetham, MD; Farida Chentli, MD; Richard N. Clayton, MD; Mark Cohen, MD; Trevor Cole, MD; Hamish Courtney, MD; Elizabeth Crowne, MD; Daniel Cuthbertson, MD; Jacob Dal, MD; Nadezhda Dalantaeva, MD; Christina Daousi, MD; Ken Darzy, MD; Professor Mehul Dattani, MD; Justin H. Davies, MD; Professor Julian Davis, MD; Margaret De Castro, MD; Laura De Marinis, MD; Professor William Drake, MD; Pinaki Dutta, MD; Larisa Dzeranova, MD; Britt Edén-Engström, MD; Professor Rosalind Eeles, MD; Maria Elfving, MD; Marianne Elston, MD; Louise Emmerson, MD; Naomi Fersht, MD; Professor Simona Fica, MD; Stefan Fischli, MD; Daniel Flanagan, MD; Maria Fleseriu, MD; Pamela U. Freda, MD; Professor Theodore Friedman, MD; Professor Lawrence A. Frohman, MD; Patricia Gallego, MD; Evelien Gevers, MD; Edit Gláz, MD; James A. Goldman, MD; Anthony P. Goldstone; Miklos Goth, MD; Lynn Greenhalgh, MD; Joan Grieve, MD; Mirtha Guitelman, MD; Alper Gürlek, MD; Mark Gurnell, MD; Katalin Horvath, MD; Trevor A. Howlett, MD; Charlotte Höybye, MD; Steven Hunter, MD; Donato Iacovazzo, MD; Peter Igaz, MD; Warrick J. Inder, MD; Takeo Iwata, MD; Louise Izatt; Sujatha Jagadeesh, MD; Gregory Kaltsas, MD; Felicity Kaplan, MD; Niki Karavitaki, MD; Darko Kastelan, MD; Michelle Katz, MD; Tara Kearney, MD; Bernard Khoo, MD; Cathy Kiraly-Borri, MD; Robertas Knispelis, MD; Gábor László Kovács, MD; Ajith V. Kumar, MD; Edward R. Laws Jr, MD; Ronald M. Lechan, MD; Miles J. Levy, MD; Krzysztof Lewandowski, MD; Janet Lo, MD; Niki Maartens, MD; Professor Akira Matsuno; Barbara McGowan, MD; Siobhán E. McQuaid, MD; Milica Medic-Stojanoska, MD; Professor Moisés Mercado-Atri, MD; Emese Mezősi, MD; Dragana Miljic, MD; Karen K. Miller, MD; Silvia Modenesi, MD; Mark E. Molitch, MD; Professor John Monson, MD; Damian G. Morris, MD; Patrick J. Morrison, MD; Alia Munir, MD; Professor Robert D. Murray, MD; Madalina Musat, MD; Nina Musolino, MD; Lisa Nachtigall, MD; Professor John Newell-Price; Arla Ogilvie, MD; Steve M. Orme, MD; Ionela Paşcanu, MD; Attila Patócs, MD; Catherine Patterson, MD; Simon H. Pearce, MD; Francesca Pecori Giraldi, MD; Professor Marija Pfeifer, MD; Professor Vera Popovic; Nicola Poplawski, MD; Michael Powell, MD; Peter Pullan, MD; Richard Quinton, MD; Serban Radian, MD, PhD; Harpal Randeva, MD; Antônio Ribeiro-Oliveira Jr, MD; Celia Rodd, MD; Fiona Ryan, MD; Roberto Salvatori, MD; Professor Christof Schöfl; Debbie Shears, MD; Kevin Shotliff, MD; Beatriz S. Soares, MD; Noel Somasundaram; Professor Anna Spada, MD; James Sperber, MD; Helen A. Spoudeas, MD; Susan Stewart, MD; Helen Storr, MD; Christian Strasburger, MD; Maria Elisabeth Street, MD; Francesca Swords, MD; Professor Rajesh V. Thakker, MD; Elaine Tham, MD; Chris Thompson, MD; Dr Michael O. Thorner; Miklós Tóth, MD; Professor Peter J. Trainer, MD; Stylianos Tsagarakis, MD; Marinella Tzanela, MD; János Vadász, MD; Vladimir Vaks, MD; Rasa Verkauskiene, MD; Professor John A. Wass, MD; Susan M. Webb, MD; Astrid Weber, MD; Shozo Yamada, MD; Sema Yarman, MD; Philip Yeoh, MD; Katsuhiko Yoshimoto, MD; and Nicola N. Zammitt, MD. Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective diagnosis in AIP mutation carriers. J Clin Endocrinol Metab 2015;100: E1242–E1254.
Ipekci SH, Cakir M, Kıyıcı A, Koc O, Artac M. Radiotherapy-induced hypopituitarism in nasopharyngeal carcinoma: the tip of an iceberg. Exp Clin Endocrinol Diab 2015;123:411-418.
Tanriverdi F, Dokmetas HS, Kebapcı N, Kilicli F, Atmaca H, Yarman S, Ertorer ME, Erturk E, Bayram F, Tugrul A, Culha C, Cakir M, Mert M, Aydin H, Taskale M, Ersoz N, Canturk Z, Anaforoglu I, Ozkaya M, Oruk G, Hekimsoy Z, Kelestimur F, Erbas T. Etiology of hypopituitarism in tertiary care institutions in Turkish population: analysis of 773 patients from pituitary study group database. Endocrine 2013 Dec 14: epub ahead of print. 
Cakir M, Grossman A. The molecular pathogenesis and management of bronchial carcinoids. Expert Opin Ther Targets 2011;15:457-491.
Cakir M, Levendoglu F, Kiyici A, Coskun Y. Serum CXCL 10 Levels and Neuromuscular Manifestations in Patients with Autoimmune Thyroid Diseases. Autoimmunity 2011;44:496-503.
Cakir M, Dworakowska D, Grossman A. Somatostatin receptor biology in neuroendocrine and pituitary tumors: part 1- molecular pathways.J Cell Mol Med 2010;14:2570-2584.
Cakir M, Dworakowska D, Grossman A. Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 2- clinical implications. J Cell Mol Med 2010;14:2585-2591.
Kok K, Wong SP, Huda MS, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JP, Pinkney JH. In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1. Diabetes Obes Metab 2010;12:360-363.
Cakir M, Grossman AB. Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis. Expert Opin Ther Targets 2009;13:1121-1134.
Dworakowska D, Wlodek E, Leontiou C, Igreja S, Cakir M, Teng M, Prodromou N, Goth M, Grozinsky-Glasberg S, Gueorguiev M, Kola B, Korbonits M, Grossman A. Activation of Raf/MEK/ERK and PI3K/Akt/mTOR pathways in pituitary adenomas and their effects on  downstream effectors.Endocr Relat Cancer 2009;16:1329-1338.
Cakir M, Grossman AB. Medullary Thyroid Cancer: Molecular biology and novel molecular therapies. Neuroendocrinology 2009;90:323-348.
Cakir M, Kayacetin E, Toy H, Bozkurt S. Gallbladder motor function in patients with different thyroid hormone status. Exp Clin Endocrinol Diabetes 2009;17:395-399.
Cakir M, Arıcı C, Alakuş H, Altunbaş H, Balcı MK, Karayalcin U. Incidental thyroid carcinoma in thyrotoxic patients treated by surgery. Horm Res 2007;67:96-99.
Cakir M, Sari R, Tosun O, Saka O, Karayalcin U. Reproducibility of fasting and OGTT-derived insulin resistance indices in normoglycemic women. Can J Diab 2006;30:46-51.
Cakir M, Sarı R, Tosun O, Karayalcin U. Cortisol levels during an oral glucose tolerance test in lean and obese women. Endocr Res 2005;31:213-218.
Erdoğan MF, Gürsoy A, Özgen G, Cakir M, Bayram F, Ersoy R, Algün E, Cetinarslan B, Cömlekçi A, Kadıoglu P, Balcı M, Yetkin İ, Kabalak T, Erdoğan G. Ret proto-oncogene mutations in apparently sporadic Turkish medullary thyroid carcinoma patients: Turkmen Study. J  Endocrinol Invest 2005;28:806-809.
Cakir M, Sari R, Tosun O, Karayalcin U. Leptin response to oral glucose tolerance test in obese and nonobese premenopausal women. Endocr Res 2005;31:1-8.
Dora B, Mihci E, Eser A, Ozdemir C, Cakir M, Balci MK, Balkan S. Prolonged hyperglycemia in the early subacute period after cerebral infarction: effects on short term prognosis. Acta Neurol Belg 2004;104:64-67.
Sari R, Balci MK, Cakir M, Altunbas H, Karayalcin U. Comparison of efficacy of sibutramine or orlistat versus their combination in obese women. Endocr Res 2004;30:159-167.
Cakir M, Samanci N, Balci N, Balci MK. Musculoskeletal manifestations of patients with thyroid disease. Clinical Endocrinology 2003;59:162-167.
Kilicarslan AB, Ogus M, Arici C, Pestereli HE, Cakir M, Karpuzcuoglu G. Clinical importance of vascular endothelial growth factor (VEGF) for papillary thyroid carcinomas. APMIS 2003;111:439-443.
Arican A, Içli F, Akbulut H, Cakir M, Sencan O, Samur M, Acikgoz N, Demirkazik A. The effect of two different doses of oral clodronate on pain in patients with bone metastases. Med Oncol 1999;16:204-210.Ferrara AM, Cakir M, Henry PH, Refetoff S. Coexistence of THRB and TBG gene mutations in a Turkish family. J Clin Endocrinol Metab 2013;98:1148-1151.
Kaya A, Cakir M, Turan E, Kulaksızoglu M, Taştekin G, Altınok T. Normocortisolemia after ten days of octreotide treatment in a patient with ectopic Cushing’s syndrome due to bronchial carcinoid. Acta Endocrinologica 2013;9:467-472.
Gonulalan G, Esen H, Erikoglu M, Cakir M. Thyroid Lipomatosis. Int Med 2012;51:3383-3385.
Cakir M. Significant hyperkalemia and hyponatremia secondary to telmisartan/hydrochlorothiazide treatment. Blood Press 2010;19:380-382.
Cakir M, Gonen S, Dikbas O, Ozturk B. Thyroid hemiagenesis with Graves' disease, Graves' ophthalmopathy and multinodular goiter. Intern Med 2009;48:1047-1049.
Cakir M. Euthyroid Graves` ophthalmopathy with negative autoantibodies. J Natl Med Assoc 2005;97:1547-1549.
Cakir M. A case of Marine-Lenhart syndrome. J Natl Med Assoc 2005;97:1036-1038.
Cakir M, Mahsereci E, Altunbas H, Karayalcin U. A case of rhabdomyolysis associated with thyrotoxicosis. J Natl Med Assoc 2005; 97:732-734.
Cakir M, Arici C, Tacoy S, Karayalcin U. A case of Costello syndrome with parathyroid adenoma and hyperprolactinemia. Am J Med Genet 2004;124A:196-199.
Cakir M, Karayalcin U. Graves` disease coexisting with probable autoimmune hypoparathyroidism. Exp Clin Endocrinol Diabetes 2003;111:374-376.
Cakir M, Altunbas H, Balci MK, Karayalcin U, Karpuzoglu G. Medullary thyroid carcinoma, follicular variant. Endocr Pathol 2002;13:75-79.
Cakir M, Gurkan OU, Savas I, Numanoglu N, Ataman S, Ekinci C, Akar N. Extensive jugular and upper limb thrombosis in a patient with factor V Leiden  mutation and Non-Hodgkin`s lymphoma. Austr NZ J Med 2000;30:735-736.
Ustun C, Ozcan M, Gurman G, Cakir M, Erekul S, Akyol G, Arat M, Celebi H, Idilman R, Akan H, Ilhan O, Demirer T, Beksac M, Koc H. Differences in liver pathology and clinical outcome between two patients with hepatitis B virus and graft versus host disease. Pathol Oncol Res 1999;5:229-232.  
Cakir M. Hashitoxicosis (or Graves disease?) with pericadial effusion. Int J Cardiol 2010;145:298.
Cakir M. Takotsubo cardiomyopathy in thyrotoxicosis. Int J Cardiol 2010;145:499-500.
Cakir M. Re: testosterone levels among men with spinal cord injury: relationship between time since injury and laboratory values. Am J Phys Med Rehabil 2009;88:1033.
Cakir M. Levels of testosterone and gonadotrophins in men with long-standing tetraplegia. Spinal Cord 2009;17:395-399.
Cakir M. Nerve growth factor levels in autoimmune thyroid diseases. Cytokine 2007;39:97-98.
Cakir M, Can İ. Cardiovascular abnormalities in hyperthyroidism. Am J Med 2006;119:187-188.
Cakir M, Akın M, Karayalcin U. Prolonged hypoglycemia secondary to extended-release form glipizide. Diabetes Obes Metab 2004;6:310-311.
Cakir M. Diagnosis of Marine-Lenhart syndrome. Thyroid 2004;14:555.
Cakir M, Altunbas H, Karayalcin U. Hyperglycemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes. JCEM 2003;88:1402.
Cakir M. Differential Diagnosis of Hyperthyroidism. Endocrinology Research and Clinical Developments Series. Nova Science Publishers, Inc., New York, 2010.Cakir M. Differential Diagnosis of Hyperthyroidism. In: Handbook of Hyperthyroidism: Etiology, Diagnosis and Treatment (Mertens L, Bogaert J eds.), Nova Science Publishers, Inc., New York, 2009.

Major Research Interests
Thyroid diseases
Utoimmune thyroid diseases and nodular goiter
Certified and experienced in fine needle aspiration biopsy of thyroid nodules
Pituitary and adrenal gland diseases

Association
The Society of Endocrinology and Metabolism of Turkey
Neuroendocrinology Society
Endocrine Society
European Society of Endocrinology
Society for Endocrinology
European Neuroendocrine Tumor Society
European Thyroid Association